ith him?

Experienced and professional animal trainer provide their insights in answering this question :
A. Amitriptyline can sometimes cause adverse reactions in the heart, kidney or liver, especially in cats with kidney or liver disease. It is best to contact your vet first and see if they feel comfortable giving a trial dose of the medication. Your vet may wish to monitor your cat’s bloodwork during this time to watch for any adverse effects.

There are other products available that may also help such as Feli-way which is a wall plug-in (or collar) that releases a natural pheromone to calm cats and is commonly used for inter-cat aggression. As the product is not ingested it may be safer to use on a cat with underlying health conditions.

How to Identify Common Pet Problems ?

Our sources include academic articles, blog posts, and personal essays from experienced pet care professionals :

Amitriptyline can help decrease aggressive behavior between cats and can help treat unwanted behaviors such as urine spraying, urinating or defecating outside of the litter box.
Taking opioid-based medicines, like codeine, morphine or oxycodone, together with amitriptyline can increase your risk of becoming very drowsy and having breathing problems. Tell your doctor if you have ever taken any medicines for depression.
Amitriptyline (brand names: Elavil®, Levate®) is a tricyclic antidepressant used to treat behavior disorders in small animals, such as generalized and separation anxiety in dogs, and excessive grooming, urine spraying, lower urinary tract disease, and anxiety in cats.
You may start to feel better after 1 to 2 weeks but it can take 4 to 6 weeks for amitriptyline to work fully. Side effects such as a dry mouth and constipation are common. They`re usually mild and go away after a couple of weeks. It`s best to take amitriptyline in the evening or before you go to bed.
In cases of frequent or unpredictable aggression, a daily medication like fluoxetine may be useful. When aggression is infrequent and predictable, trazodone or gabapentin before the triggering event works well for many cats.
This side effect wasn`t common in studies of the drug. But drugs used to treat depression, such as amitriptyline, may cause mood or behavior changes. Mood or behavior changes from amitriptyline can include: feeling aggressive, violent, or irritable.
Amitriptyline may interact with other antidepressants and sedatives (like opioids and alcohol). It can also interact with medications like diphenhydramine (Benadryl). Always check with your healthcare provider and pharmacist before starting amitriptyline. They can help you check for amitriptyline interactions.
Amitriptyline can increase the risk of suicidal thoughts and behavior, especially in children, adolescents, and young adults. People of all ages who are started on antidepressant therapy should be watched closely for signs of changes in behavior or worsening depression.
In cats, the issues reported were vocalizing, dilated pupils, increased heart rate, incoordination, lethargy and disorientation, and nausea. Tricyclic antidepressants such as amitriptyline cannot be safely used with monoamine oxidase inhibitors such as Deprenyl (Anipryl®) or with tramadol, a pain reliever.
Dosing Information of Amitriptyline HCl for Dogs and Cats

For dogs, the dose is 0.5 to 2 mg per pound (1 to 4 mg/kg) given every 12 to 24 hours, orally. For cats, the dose is 2 to 10 mg per cat (most often 5 to 10 mg/cat) once daily.

“Lithium and Elavil (amitriptyline), two mood stabilizers, are also potentially harmful for the kidneys. These psychiatric medications can cause muscle breakdown, leading to the release of myoglobin into the bloodstream. Since the kidneys work to filter myoglobin, kidney damage happens as a result,” said Ngo-Hamilton.
The 2015 Cochrane systematic review of nortriptyline for neuropathic pain reiterates the general view that “nortriptyline is sometimes preferred to amitriptyline because it reputedly has a lower incidence of associated adverse effects.”3 The reviewers subsequently describe the state of adverse event reporting in …
Some of the underlying non-medical causes for aggression between cats in the same household include fear, lack of socialisation, inappropriate introduction of a new cat, overcrowding (i.e. not enough vertical or horizontal space, too few resources etc), redirected aggression, play and predation.
It is very important not to console an aggressive cat, as this may be perceived as approval of aggression. It is also important not to retreat or show fear, as this may reinforce the behavior if your retreat is what the cat wants. Lack of attention is a better way to handle fear aggression.
The case settled prior to trial for $1,000,000. Lubin & Meyer attorneys represented the plaintiff in this amitriptyline toxicity lawsuit.
Although Elavil was discontinued, the generic form of the drug is still available and prescribed by doctors.
Amitriptyline may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed.
Amitriptyline contains a half-life of approximately 20 hours. This means that a person who takes a 20-mg dose of the medication would only have 10 mg in their system after 20 hours have elapsed. After another 20 hours have elapsed, a person would have 5 mg of the drug in their system.
Using amitriptyline together with mirtazapine can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred …
Painkillers with amitriptyline

If you need to take a painkiller it`s safe to take paracetamol, aspirin or ibuprofen with amitriptyline. However, it`s best to avoid taking co-codamol, codeine or other opioid painkillers because these could worsen any drowsiness or constipation that you may be experiencing.

Amitriptyline may decrease the excretion rate of Prednisone which could result in a higher serum level. Prednisone may decrease the excretion rate of Ammonium chloride which could result in a higher serum level.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of amitriptyline in the elderly. However, elderly patients are more likely to have age-related liver problems, which may require an adjustment in the dose for patients receiving amitriptyline.
A higher dose of amitriptyline (10 mg) was more effective than a lower dose (5 mg) in alleviating neck pain, disability, sleep problems, and anxiety and depression symptoms in patients with idiopathic and nontraumatic CNP, without increasing the rate of adverse effects.
Amitriptyline (Elavil, Endep) is a tertiary amine tricyclic that is sedating.

Relevant Questions and Answers :

the most relevant questions and answers related to your specific issue

Q. Why do cats meow?
ANSWER : A. Cat parents often wish they could better understand what their favorite feline friends want or desire. A cat’s meow can be interpreted in many different ways and can indicate an array of feelings and needs. Here are some of the most common reasons for your cat’s vocalizations:

1. Greeting- Many cats will meow as a greeting when you enter your home or walk into a room. Cats will also meow at another cat or animal in the household to extend a hello and acknowledge the other animal’s presence.

2. Attention – An exuberant meow followed by leg rubbing or another attention seeking behavior may indicate your cat is looking for some quality time spent together. Some petting or rubbing behind the ears may be in order.

3. Hunger – A meowing cat is often a hungry cat. This is one of the most common reasons for a cat to vocalize to their owners. A cat will meow to get your attention at feeding times or even when they want extra food.

4. Sickness – A sick or hurt cat may begin to meow excessively, warranting a visit to the veterinarian. There are numerous reasons for a cat in distress to meow—whether it is related to an upset stomach, an injured leg or a urinary blockage. These meows should be carefully investigated.

5. Entering or leaving – Most cats will vocalize when they want to be let in or out of a room. You may notice when you are in the bathroom or behind the closed door of a room that your cat begins to meow, scratches at the door, and often reaches its paw under the door. This is a clear indication that the cat wants to be where you are.

6. Angry – An agitated cat may meow to warn their owner or another household pet that they are upset and would like to be left alone. This angry meow may increase in sound volume as the cat becomes more stressed or agitated. Often a cat will exhibit this type of meow at the veterinary office when they are unhappy with their examination or restraint.

Each feline is different and so are their vocalizations. Learn to understand the variety of meows your cat uses on a daily basis. This will help you develop a better relationship with your cat and help them live a more trusting and happier life.

Q. 16 year old cat has kidney disease but is aggressive with another cat . Are there any contraindications for doing a trial of Amitriptyline with him?
ANSWER : A. Amitriptyline can sometimes cause adverse reactions in the heart, kidney or liver, especially in cats with kidney or liver disease. It is best to contact your vet first and see if they feel comfortable giving a trial dose of the medication. Your vet may wish to monitor your cat’s bloodwork during this time to watch for any adverse effects.

There are other products available that may also help such as Feli-way which is a wall plug-in (or collar) that releases a natural pheromone to calm cats and is commonly used for inter-cat aggression. As the product is not ingested it may be safer to use on a cat with underlying health conditions.

Q. My cat continues to scratch on furniture and carpets. He has plenty of scratching posts around the house. Please help!
ANSWER : A. Scratching is a natural behavior in cats that can be frequently frustrating for pet owners who want to keep their furniture from being shredded on a constant basis. The texture of furniture and carpet is very appealing to cats and this why they frequently choose to spend their time on this activity as opposed to playing with their own cat toys. Here are some suggestions to help curb this unwanted behavior:

1. Purchase a cat scratching post or cat tree that is covered in carpeted or textured material. Place it in an appealing spot that your cat would be inclined to spend time (eg. in the sun). You can also place catnip on the scratching post or cat tree to make your cat even more interested in the new object.

2. You can utilize double sided tape on the ends of the furniture because you cat will not like the sticky feeling and will learn to not scratch in that region. Use the tape that has a lighter adhesive in order to prevent any permanent damage. Other materials, such as aluminum foil or bubble wrap can also be placed on the furniture to discourage the scratching.

3. Keep nails trimmed short by either learning to do this on your own at home or using a veterinary technician, or groomer. Nails can usually be trimmed every 6-8 weeks.

4. Redirect the unwanted behavior. If your cat begins scratching, use a favorite or new toy to distract the cat from the scratching. Give your cat positive praise for not scratching.

5. As a last resort you can use a spray bottle full of water to spritz your cat when he or she is scratching inappropriately at your furniture. Generally, cats do not like water and this will discourage them from continuing the behavior.

Have patience with your cat because it can takes time to understand this is an unwanted behavior and that furniture is not another toy for them to use. You can always consult your veterinary or veterinary behaviorist to help with ideas or further solutions to this problem.

Read Full Q/A … : I found Pickle on

Q. How should I interpret my cat’s tail movements?
ANSWER : A. Our feline friends express themselves in many different ways, including through the use of their tails. Most pet owners pay close attention to a happy or excited dog, but they are sometimes less attentive to the posture and movement of their cat. Here are some of the most common cat tail behaviors, and the underlying emotion behind each action:

A flicking tail: Many anxious, nervous or stressed cats will hold their tail in a low position and flick it quickly back and forth. This is often referred to as angry tail, and a pet owner or veterinarian should be on guard for any possible aggressive or defensive activity. If a cat is moving their tail slowly, and not exhibiting the flicking motion, then this cat is at a much calmer state.

Vertical position: Most of the time when a cat is holding their tail in a straight, vertical position this is indicating curiosity and a playful mood. A cat chasing after a laser pointer or playing toys will often have their tails in a vertical position showing their enjoyment. This position also helps with balanced movements. In contrast, if the tail is in the vertical position and the cat’s back is arched with pinned back ears then this could demonstrate a feeling of being threatened and thus result in defensive or aggressive behaviors.

The Tucked Tail: Similar to a dog, a tucked tail often indicates submission or fear. Your cat is conveying upset feelings and should most likely be left alone. This tucked tail appearance can also make a cat look smaller and less threatening to an aggressive cat.

The Tail Twine: Cats will often hook their tail around another cat’s tail, owner’s legs or other objects to show a friendly and affectionate nature. They are also trying to indicate whether they want to receive affection from their owners, be fed or have playtime.

The next time you are home with your feline companion take note on how they express themselves through their tail movements, their ears, body posture and vocalization. You can start to better understand their needs and wants, in addition to what makes them uncomfortable or happy. Cats will surprise you with their array of emotions and varied expressions they can express.

Q. Our cat of six years has on two separate occasions has defecated on the living room rug and recently pee’d on the skirt of the Christmas tree.
ANSWER : A. Inappropriate elimination in cats is often a behavioral problem rather than a medical problem, so the first step is to have him seen by your vet to eliminate any kind of illness or condition as a cause for his eliminating outside the box.

If medical issues are ruled out, take a look at other reasons. Has there been a lot of unusual activity? Has you cat been left at home or boarded? Is the litterbox in a busy area? Has anything happened recently in this area to make him reluctant to use it again? Is there another cat, pet or person that is preventing him from getting to the box? Have you changed it from a hooded to an open box, or vice versa? Is it big enough? Have you changed the type or brand of litter? Is there something attractive about the spot he uses? Cats dislike disturbances to their routine and may act out to express their dissatisfaction.

The general rule is one litter box per cat in the household, plus one. That way each cat can have a place of their own to go in case the box is occupied or another cat has claimed it as territory. They should be scooped daily, if not more often and changed completely weekly, washed with soap and water only. You can offer one kind of litter in one box and another kind in another to see if there is a preference. I don’t recommend the crystals, it makes a hissing sound when wet that startles some cats and make them reluctant to use it again. The litter boxes should be located in a quiet, low-traffic area so that the cat can use them in peace. Make sure any other pets or people aren’t giving them a hard time around or in the litter box. It may take some investigation and experimentation to find your cat’s preference and accommodate him so that everyone is satisfied with the situation. And, when cleaning up pet accidents, don’t use any cleaner containing ammonia. This leaves behind a scent similar to urine.

Q. I have a cat that defecates in the litter box but always urinates outside the box. It is very annoying.
ANSWER : A. Inappropriate elimination in cats is often a behavioral problem rather than a medical problem, so the first step is to have him seen by your vet to eliminate any kind of illness or condition as a cause for his eliminating outside the box.

If medical issues are ruled out, take a look at other reasons. Has there been a lot of unusual activity? Has you cat been left at home or boarded? Is the litterbox in a busy area? Has anything happened recently in this area to make him reluctant to use it again? Is there another cat, pet or person that is preventing him from getting to the box? Have you changed it from a hooded to an open box, or vice versa? Is it big enough? Have you changed the type or brand of litter? Is there something attractive about the spot he uses? Cats dislike disturbances to their routine and may act out to express their dissatisfaction.

The general rule is one litter box per cat in the household, plus one. That way each cat can have a place of their own to go in case the box is occupied or another cat has claimed it as territory. They should be scooped daily, if not more often and changed completely weekly, washed with soap and water only. You can offer one kind of litter in one box and another kind in another to see if there is a preference. I don’t recommend the crystals, it makes a hissing sound when wet that startles some cats and make them reluctant to use it again. The litter boxes should be located in a quiet, low-traffic area so that the cat can use them in peace. Make sure any other pets or people aren’t giving them a hard time around or in the litter box. It may take some investigation and experimentation to find your cat’s preference and accommodate him so that everyone is satisfied with the situation. And, when cleaning up pet accidents, don’t use any cleaner containing ammonia. This leaves behind a scent similar to urine.

Q. My cat started to pee outside the litter box. What should I do?
ANSWER : A. Inappropriate bathroom use in cats is often a behavioral problem rather than a medical problem, so the first step is to have him seen by your vet to eliminate any kind of illness or condition as a cause for his defecating outside the box.

Once medical issues are ruled out, it’s time to take a look at other explanations. Has there been a lot of activity that wasn’t normal? Were you away and your cat was left at home or boarded? Is the litterbox located in a busy area? Has anything happened recently in this area to make him reluctant to use it again? Is there another cat, pet, or person that is preventing him from getting to the box? Have you changed it from a hooded to an open box, or vice versa? Have you changed the brand of litter or kind? Or is there something about the spot he has chosen to use that is attracting him in some way? Cats dislike disturbances to their routine and may act out as a way of expressing their dissatisfaction.

The general rule of thumb is one litter box per cat in the household, plus one. That way each cat can have a place of their own to go in case the box is occupied or another cat has claimed it as territory. They should be scooped at least daily, if not more often and changed completely on a weekly basis, and washed with soap and water.

You can also offer one kind of litter in one box and another kind in another to see if there is a preference. I don’t recommend the crystal kind, since it makes a hissing sound when wet that can startle some cats and make them reluctant to use it again.

The litter boxes should be located in a quiet, low-traffic area so that the cat can use them in peace. Make sure other pets or people aren’t giving them a hard time around or in the litterbox. It may take some investigation and experimentation to find your cat’s preference and accommodate him so that everyone is satisfied with the situation.

Q. Aggressive young cat attacking my other cat?
ANSWER : A. Aggression among cats can be a sign of stress, especially if one cat has just been introduced, or if the other cat is overly curious/friendly toward the scared one. The best first step is to make sure each cat has their own separate “spaces” where they can go to get away from harassment from the other cat. Up-high bedding, quiet rooms, etc can all help. Make sure each cat also has their own litter box and food/water bowls as cats often do not like to share and this can be a point of aggression between them. Lastly, placing pheromone diffusers or pheromone calming collars on one or both cats may help decrease stress and aggression through the use of cat calming pheromones. Fel-i-way is one of the most common brands.