Experienced and professional animal trainer provide their insights in answering this question :
A. No, at least they are not known yet.

How to Identify Common Pet Problems ?

Our sources include academic articles, blog posts, and personal essays from experienced pet care professionals :

Side Effects: Monitor your dog after application. Side effects, although very rare, may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported.
Most veterinarians consider Advantix safe for dogs, but it is a strong medication that should be used with caution. The main active ingredients are imidacloprid and permethrin, both of which can be toxic in high doses.
Your pet may also experience lethargy, drooling, and vomiting. These effects should clear up in a few days and relief can be accelerated by removing the formula with a detergent shampoo; however, it is important to avoid bathing or shampooing your pet for the first 48 hours following its application.
Simparica is an excellent choice for flea and tick protection. The monthly chew also comes with an option for heartworm protection, too, as Simparica Trio. But while Simparica is usually safe flea and tick treatment for dogs, it shouldn`t be prescribed to dogs with a history of seizures.
The biggest difference between these medications is that K9 Advantix II kills AND repels fleas, ticks, mosquitoes, and chewing lice, but Frontline Plus kills these pests AND prevents fleas from laying new eggs. Pregnant dogs are also approved to use Frontline Plus, and vets must be consulted to use K9 Advantix II.
In very rare occasions skin reactions such as hair loss, redness, itching and skin lesions may occur. Agitation and disorientation has also been reported. Excessive salivation and nervous signs such as incoordination, tremors and depression have been reported exceptionally in dogs.
Adverse reactions in dogs treated with Advantage Multi for Dogs included hematochezia, diarrhea, vomiting, lethargy, inappetence, and pyoderma.
If your dog is pregnant, breeding, or lactating, K9 Advantix II is the safest choice. If your dog would benefit from protection against biting flies and mosquitoes, you might lean toward that K9 Advantix II. If sarcoptic mange is a concern, Seresto is a great treatment option.
Overdosing or over-treating your dog with K9 Advantix II or any other flea and tick medication can lead to serious health problems, including toxicity, seizures, and even death.
Although K9 Advantix® II kills fleas on your dog, there may still be fleas in your dog`s environment that have since jumped on after treatment. Luckily, with K9 Advantix® II, new fleas are killed within 2 hours with protection against further infestation for at least 4 weeks.
Best Overall: Frontline Plus Topical Treatment

The most frequently recommended is a topical treatment. Frontline Plus is a well-established product: “For more than 20 years, veterinarians and pet owners have been using Frontline Plus for Dogs to effectively prevent, treat, and control fleas,” writes DogProductPicker.

Fleas and ticks can carry and transmit diseases, which is why preventing infection is important. Preventatives are types of medication that can be safely and routinely given to deter fleas and ticks from biting your dog.
While K9 Advantix II for dogs is safe when used as directed, it can be fatal for cats. Permethrin, one of the active ingredients in K9 Advantix II, is toxic to cats. Pet parents of cats and dogs must isolate their cats for at least 24 hours following treatment.
Advantage vs Advantix

K9 Advantix II has the added benefit of killing and repelling ticks and mosquitoes, whereas Advantage has no effect on these parasites at all. Actively `Repelling` ticks and mosquitoes is a massive benefit in areas where things such as Lymes disease, heartworm and tapeworms are prevalent.

It is very important to separate dogs from cats in the household for 24 hours after applying permethrin-based spot-on medicine to dogs. If you apply a cat-safe flea and tick spot-on product to your cat, be sure to do it at the nape of the neck. This should keep the cat from reaching and licking the product.
Incorrectly applying topical flea prevention is the most common cause for why it`s not working. Topical medication should be applied directly to the skin, not to your pet`s fur. You must part their hair so you can apply it to the skin.
Brands like Vectra 3D, K9 Advantix, Bio Spot-on, and some Hartz products contain permethrin, which is extremely toxic to cats (Handley, n.d.). The reason for this is because cats lack enzymes in their liver to effectively break down certain chemicals, permethrin being one of them.
Advantix is CONTRAINDICATED for use in cats. Cats are highly sensitive to permethrin due to their unique physiology and inability to metabolise certain chemicals. Use of Advantix on cats may have serious harmful effects, including death. Keep cats separated from recently treated dogs.
We advise applying Advantage once a month to help protect your pet against fleas. Step 1: Choose the correct Advantage product suitable for your dog`s weight.
However, both dogs and cats can have serious adverse reactions to some of these ingredients, even when the product is used according to label directions. Side effects can include skin irritation, agitation or lethargy, vomiting, tremors and seizures.
In March 2021, USA Today announced two pet owners filed a class-action lawsuit against Elanco Animal Health, a pet pharmaceutical company owning rights to the Seresto flea and tick collar for cats and dogs.
Frontline pus for cats has the same effectiveness as frontline plus for dogs except that it does not work in eliminating ticks. So, if you are concerned about ticks on your furry pal then Frontline plus is the best option. While if adult fleas, flea larvae and chewing lice is you concern then you can opt for Advantage.
A single application of K9 Advantix® II remains effective for four weeks. However, if the dog has a severe infestation, retreatment within a month may be necessary.
If you have a multi-pet household, keep treated pets apart for 24 hours while the spot-on treatment absorbs, Dr. Wooten says. Monitor your pet, and keep them from rolling around. Your pet will feel the treatment on their skin, and may want to rub it off, so it`s important to keep a watchful eye on them, she adds.

Relevant Questions and Answers :

the most relevant questions and answers related to your specific issue

Q. What are the longterm effects of phenobarbitol in dogs?
ANSWER : A. The desire effect is control of seizures. The side effects which you may be referring to in your question are sleepiness, tiredness, increased thirst and appetite, weight gain, elevated liver enzymes. There is much longer list of possible side effects but they are rather uncommon.

Q. Are there any serious counter-indications to mange medications?
ANSWER : A. In canine Demodicosis temporary sedation is the most common side effect of Amitraz, and it may not occur with subsequent treatments.

Pruritus, sedation, weakness and ataxia are also noted in some cases.

Also, Amitraz should not be used in Chihuahuas.

Mylbemicin has also been used as treatment for 90 days with a 60% success rate. Dosage might need to be increased if mites are present after the initial 30 days, and side effects at higher dosage include trembling, ataxia,vomiting and stupor.

Similar side effects are reported with treatment with Ivermectin. Collie and Collie Cross, and some herding dogs should not be treated with Ivermecting because of the effects on the Central Nervous System.

Q. What are the long term side effects of Tramadol in dogs?
ANSWER : A. Lethargy, sleepiness, dullness, constipation are the most common side effects. As Tramadol has been used extensively in veterinary medicine only for a few years there may be more side effects that we are still not aware of.

Q. My vet just put my dog on an antihistamine and antibiotic. Her appetite seems to be diminished – about 1/2 of what she usually eats. Is that normal?
ANSWER : A. Side effects vary with medication, lack of appetite can be a side effect for some. I would give a quick call to your vet to let them know about the appetite, it may be a side effect or maybe something needs to be adjusted.

Q. Adequan by shot or Rimadyl by pill–which is safer long term for my lab?
ANSWER : A. The two medications have different mechanism of action and different efficacy. Adequan (polysulfated glycosaminoglycans) is safer and in the long term has less side effects if used at appropriate dosage/regime and administer correctly by your veterinarian.

Do not consider Adequan a 100% safe product anyway. Side effects can include: pain at injection sites, decreased platelets numbers and kidney/liver toxicities. These side effects are not common if correct dosages are used.

Q. If there is a side effect of blood in urine due to metronidazole, how do you treat it?
ANSWER : A. Bladder inflammation is a rare side effect of metronidazole described in human. It would be a very unusual side effect of this antibiotic in your dog. I would suggest you to contact your vet who is likely to prescribe different antibiotics for your dog.

Q. My dog was given a prednisone shot because of an allergie. She has had since the shot , drinking tonds of water . How long does de side effects last ,
ANSWER : A. Excessive thirst is an extremely common side effect of prednisone. The effects of the drug usually last about 3 days. If the excessive thirst continues past that point, or if there are other concerning signs, call your vet to discuss.

Q. Question about prednisone.She is on 2pills every other day. It makes her restless and extremely thirsty, having to urinate excessively.1 pill a day?
ANSWER : A. Excessive thirst and excessive urination are side effects of prednisone. You didn’t mention why she is on it, and it treats an enormous variety of diseases, so I cannot advise you to reduce the dose as she may have a serious recurrence of whatever she’s on it for. One of the very difficult things about pred is managing the side effects while maintaining the remission from the disease that the pred helped us get.

Consult your vet about changing the dosage. For some conditions other immunosuppressive drugs can be used along with pred, which might be an option for your dog and might help you lower the pred or get off it completely.