Experienced and professional animal trainer provide their insights in answering this question :
A. There are generally a low number of animals that actually exhibit clinical signs when being administered NexGard or any oral flea/tick preventative. These clinical sings would be vomiting, dry skin, diarrhea, lethargy, and lack of appetite.

If your animal experiences any of the clinical signs it is recommend you discontinue the medication and contact both your veterinarian and the company.

How to Identify Common Pet Problems ?

Our sources include academic articles, blog posts, and personal essays from experienced pet care professionals :

Since the release of NexGard, adverse events that have been reported for dogs are listed here in decreasing order of reporting frequency: Vomiting, pruritus, lethargy, diarrhea (with and without blood), anorexia, seizure, hyperactivity/ restlessness, panting, erythema, ataxia, dermatitis (including rash, papules), …
Yes, NexGard Chewables is safe to give to most dogs. More specifically, NexGard is safe and effective in dogs and puppies 8 weeks of age or older, weighing 4 lbs or more.
“The following adverse events reported for dogs are listed in decreasing order of reporting frequency for NexGard: Vomiting, pruritus, lethargy, diarrhea (with and without blood), anorexia, seizure, hyperactivity/restlessness, panting, erythema, ataxia, dermatitis (including rash, papules), allergic reactions ( …
Yes, Nexgard is an incredibly safe and effective prevention for fleas, ticks, and mites. However, because Nexgard is ingested and absorbed into the bloodstream, rather than applied to and spread by the oils of the skin, the few reactions that do occur can seem more dramatic.
Simparica is an excellent choice for flea and tick protection. The monthly chew also comes with an option for heartworm protection, too, as Simparica Trio. But while Simparica is usually safe flea and tick treatment for dogs, it shouldn`t be prescribed to dogs with a history of seizures.
“NexGard (afoxolaner) is one of the isoxazoline class of parasiticides. Please do NOT use any of them again. There are now two isoxazoline-related class-action lawsuits in North America — one in Quebec and the other in New Jersey. The FDA finally has required warnings on the labels and product inserts.
NexGard® Recalls & Controversies

Although there have not been any FDA recalls for NexGuard®, the FDA has put out an alert for pet owners and veterinarians. This is because there is potential for neurological adverse events in dogs and cats when they are treated with drugs that fall into the isoxazoline class.

Collars such as Seresto will repel fleas and ticks, and even prevent ticks from attaching, but they must be applied tightly enough to have skin contact. Many topical options containing permethrin (e.g. K9 Advantix II, Vectra 3D) will repel and prevent tick attachment.
Thank you for your question. I would not expect the lethargy or diarrhea to last more than 12-24 hours.
Pros: These products are generally safe, very effective, easy to apply, and kill fleas and ticks without the need for the pet to be bitten first. Cons: It takes about 24 hours for the product to spread around after application, so there will be an oily spot in the hair where it was applied.
The major difference between these two is the accessibility. Frontline Plus is available over the counter while Nexgard requires a prescription. With that said, the results of Nexgard are faster acting with a 24 hour turn around for ticks and four hours for fleas, giving your pet faster relief.
I`ve given my dog NexGard, so why do they still have fleas? NexGard works by poisoning any fleas that bite your dog. You`ll also need to treat the environment, including your home and yard, as well as your dog for maximum protection.
The answer is yes, flea and tick preventatives need to be applied year-round in order to keep your pets safe. Read on to learn more about how fleas and ticks operate, the dangers they can harbor, and how best to protect your dogs and cats.
Best Overall: Frontline Plus Topical Treatment

The most frequently recommended is a topical treatment. Frontline Plus is a well-established product: “For more than 20 years, veterinarians and pet owners have been using Frontline Plus for Dogs to effectively prevent, treat, and control fleas,” writes DogProductPicker.

The most common reason is that the fleas are being killed and the dog is no longer being bitten by them. This can cause the dog to feel itchy and uncomfortable, which may lead to restlessness. Additionally, the chemicals in some flea treatments can be irritating to dogs, leading to discomfort and restlessness.
NexGard chews have been shown to provide effective protection for a complete month: it is not required or recommended to treat more frequently than this. To ensure your dog is always protected, aim to dose your dog on the same day every month. It`s a good idea to set yourself a monthly reminder on your phone.
Many flea and tick medications are manufactured in a once-monthly topical application or pill. If you miss that monthly dose, your pet is at risk of getting flea or tick bites.
Bell says, “NexGard doesn`t actually protect your dog from all tick-borne diseases. The tick has to bite the dog before the active ingredients will kill the tick.” Unfortunately, as we all know, some pathogens are transmitted within just a few hours. (I address more about products and how to control ticks below.)
#1 Definitely Not Safe – Oral Flea And Tick Preventatives. These are the worst offenders and most dangerous to use on your dog. They`re taken orally, usually as a tasty chew for your dog. These drugs contain isoxazolines.
How often should NexGard SPECTRA be given? You should dose your dog once a month, ideally on the same day of each month.
What are the risks associated with Nexgard Spectra? The most common side effects (affecting inbetween 1 to 10 animals in 1,000 animals) were vomiting, diarrhoea, lack of energy, decreased appetite, and itching, which generally were short-lived and resolved spontaneously.
Combine 1 quart of water, 1 cup of white vinegar or apple cider vinegar, and 1 cup of baby shampoo or liquid dish soap. Use this mixture to bathe your dog once or twice a month. Vinegar kills fleas and ticks on contact and can prevent future infestations.
A homemade spray solution of one part vinegar and one part water helps keep ticks and fleas away from your pets. Pour the solution in a spray bottle and spray directly onto your pets, but be careful not to get it in their eyes.
Oil of lemon eucalyptus

The CDC and EPA both recommend oil of lemon eucalyptus as a natural tick repellent. Dog parents should be aware that pure oil of lemon eucalyptus lasts approximately two hours before reapplication is needed. This is a much shorter time period than chemical repellents like DEET.

Relevant Questions and Answers :

the most relevant questions and answers related to your specific issue

Q. My cat is excessively scrstching herself., to the point she has sores. She is strictly an indoor cat. Did have flees been treated for 2 months
ANSWER : A. For every flea you see on your pet, there are 100 more in the environment. Get your pet on a good topical or oral flea control through your vet. In flea control, you get what you pay for. Consider asking your vet for a dose of Capstar. It helps get the problem under control by killing the fleas on the pet starting in five minutes but only lasts for 24 hours.

You need to treat your home environment. If you use a pest control service, tell them you are having a flea problem and they can adjust their treatment. Use a premise spray that also contains an IGR, insect growth regulator. This keeps eggs and larvae from maturing into adults and helps break the life cycle. Also, vacuum EVERY DAY, throwing out the bag or emptying the canister every time into an outside receptacle and spraying the contents with insecticide to kill the fleas you’ve vacuumed up.

Treat your yard too, since fleas are opportunistic and will hop a ride into your home on your pant leg without you knowing it. Concentrate on areas under bushes, in the shade. Fleas are less likely to be located in open sunny areas where it gets hot.

If chemicals are a problem, you can use borax. Sprinkle it into rugs, into corners and under furniture, use a broom to work it into the fibers and let it sit for hours, days even. It won’t hurt you or your pet to have it present. Then vacuum it up, reapply as needed. Food grade diatomaceous earth can be gotten from a health food store and worked into the rugs and corners in the same way as borax. These treatments aren’t as fast and effective as chemical insecticides but they can help.

You might want to consider boarding your pet for the day at your vet, to give you the opportunity to flea bomb your house without having to worry about your pet being exposed. They can bathe your pet and give a dose of Capstar while you treat your home.

Be patient, you may have to repeat these steps multiple times 10-14 days apart to help break the flea life cycle.

Skin problems can have a variety of causes, sometimes more than one. It is important to have the problem checked by your vet to determine if there is a medical cause for your pet’s skin issues and treat accordingly.

In pets of all ages, fleas, food allergies and exposure to chemical irritants such as cleaners and soaps can be a cause. Any one of these may not be enough to trigger the breakouts, depending on how sensitive your pet is, but a combination can be enough to start the itch-scratch cycle. Finding out the cause and eliminating it is the best course of action. With flea allergies, if your pet is sensitive enough, a single bite can cause them to break out scratch enough to tear their skin.

Check for fleas with a flea comb. Look for fleas and/or tiny black granules, like coarse black pepper. This is flea feces, consisting of digested, dried blood. You may find tiny white particles, like salt, which are the flea eggs. Applying a good topical monthly flea treatment and aggressively treating your house and yard will help break the flea life cycle.

If you use plastic bowls, this is a possible cause for hair loss, though this tends to be on the chin, where their skin touches the bowl while they eat. If you suspect this to be the culprit, try changing the bowls to glass, metal or ceramic.

Food allergies are often caused by sensitivity to a protein in the food. Hill’s Science Diet offers some non-prescription options for sensitive skin as well as prescription hypoallergenic foods for more severe cases. Royal Canin carries limited protein diets that may also offer some relief. Your vet can recommend a specific diet that will help.

If there is no relief or not enough, consider getting your pet checked by a veterinary dermatologist and having allergy testing done.

Q. Which flea and tick drops are the best and why?
ANSWER : A. Your question is a good one, and unfortunately the answers are going to differ based on who you ask. Many vets are seeing resistance to Frontline, which has been the go-to product for many of us for many years. It contains the active ingredient Fipronil, which is very safe and typically extremely effective. I use it on my dogs and never see fleas or ticks. However other vets will tell you in their areas, for whatever reason, they are seeing fleas and ticks on dogs and cats on which this product was used.

Another reason opinions differ is that some people like to give an oral product, and some like to put a topical product directly on the skin. That’s a matter of personal preference mostly. Bravecto, as mentioned below, is one of those products. Most people find it safe and effective. It uses a different process that Frontline to kill fleas and ticks.

In general the products you buy over-the-counter are likely going to be less expensive and less effective than what you get from a vet. I think the reason is that the more expensive products contain newer insecticides, and likely less resistance to these products has built up in the flea and tick population but also they are maybe less “proven”, so it’s important for a vet to be involved in the use of the product in order to ensure that there won’t be a negative reaction to using it.

If I lived in an area where there was Lyme disease (in the US that’s the northeast and upper midwest) I’d most definitely add a tick collar to my standard oral or topical flea and tick prevention. AND I’d search both of my dogs everyday for ticks. It’s because nothing you buy will be 100% effective, and Lyme disease can be a very serious problem.

If you want to talk further and talk more specifically about where you live and what products you’re considering, I’d be happy to do a consult with you. Nobody here is paid to recommend products, but we do develop preferences based on what we use on our own pets and in our practices.

Q. Need help, we have done flea bath ,sprayed the house and used charts ultra guard pro and still have fleas .how can we get rid of them
ANSWER : A. For every flea you see on your pet, there are 100 more in the environment. Get your pet on a good topical or oral flea control through your vet. In flea control, you get what you pay for. Consider asking your vet for a dose of Capstar. It helps get the problem under control by killing the fleas on the pet starting in five minutes but only lasts for 24 hours.

You need to treat your home environment. If you use a pest control service, tell them you are having a flea problem and they can adjust their treatment. Use a premise spray that also contains an IGR, insect growth regulator. This keeps eggs and larvae from maturing into adults and helps break the life cycle. Also, vacuum EVERY DAY, throwing out the bag or emptying the canister every time into an outside receptacle and spraying the contents with insecticide to kill the fleas you’ve vacuumed up.

Treat your yard too, since fleas are opportunistic and will hop a ride into your home on your pant leg without you knowing it. Concentrate on areas under bushes, in the shade. Fleas are less likely to be located in open sunny areas where it gets hot.

If chemicals are a problem, you can use borax. Sprinkle it into rugs, into corners and under furniture, use a broom to work it into the fibers and let it sit for hours, days even. It won’t hurt you or your pet to have it present. Then vacuum it up, reapply as needed. Food grade diatomaceous earth can be gotten from a health food store and worked into the rugs and corners in the same way as borax. These treatments aren’t as fast and effective as chemical insecticides but they can help.

You might want to consider boarding your pet for the day at your vet, to give you the opportunity to flea bomb your house without having to worry about your pet being exposed. They can bathe your pet and give a dose of Capstar while you treat your home.

Be patient, you may have to repeat these steps multiple times 10-14 days apart to help break the flea life cycle.

Q. My 13 year old male cat is acting lethargic & doesn’t seem to be feeling well. I don’t know what’s wrong except that he has fleas. Can too many fleas
ANSWER : A. Excessive fleas can cause anemia in cats, left untreated, this can be life-threatening. I recommend getting your cat seen by your vet right away for his illness. For every flea you see on your pet, there are 100 more in the environment. Get your pet on a good topical or oral flea control through your vet. In flea control, you get what you pay for. Consider asking your vet for a dose of Capstar. It helps get the problem under control by killing the fleas on the pet starting in five minutes but only lasts for 24 hours.

You need to treat your home. If you use a pest control service, tell them you are having a flea problem and they can adjust their treatment. Use a premise spray that also contains an IGR, insect growth regulator. This keeps eggs and larvae from maturing into adults and helps break the life cycle. Also, vacuum EVERY DAY, throwing out the bag or emptying the canister every time into an outside receptacle and spraying the contents with insecticide to kill the fleas you’ve vacuumed up.

Treat your yard, since fleas will hop a ride into your home on your pant leg without you knowing it. Concentrate on areas under bushes, in the shade. Fleas are less likely to be located in open sunny areas where it gets hot.

If chemicals are a problem, you can use borax. Sprinkle it into rugs, into corners and under furniture, use a broom to work it into the fibers and let it sit for hours, days even. It won’t hurt you or your pet. Then vacuum it up, reapply as needed. Food grade diatomaceous earth can be gotten from a health food store and worked into the rugs and corners in the same way. These treatments aren’t as fast and effective as chemical insecticides but they can help.

Be patient, you may have to repeat these steps multiple times 10-14 days apart to help break the flea life cycle.

Q. How do I FINALLY rid all 4 of my cats of tapeworms after 2 years of dealing with it? Fleas seem to be controlled. I know they are the vector.
ANSWER : A. If your cats keep getting tapeworms, then they are picking up fleas from somewhere. Fleas will hitch a ride on your pant leg from outside.

Get your pet on a good topical or oral flea control through your vet. In flea control, you get what you pay for. Consider asking your vet for a dose of Capstar. It helps get the problem under control by killing the fleas on the pet starting in five minutes but only lasts for 24 hours.

You need to treat your home environment. If you use a pest control service, tell them you are having a flea problem and they can adjust their treatment. Use a premise spray that also contains an IGR, insect growth regulator. This keeps eggs and larvae from maturing into adults and helps break the life cycle. Also, vacuum EVERY DAY, throwing out the bag or emptying the canister every time into an outside receptacle and spraying the contents with insecticide to kill the fleas you’ve vacuumed up.

Treat your yard too, since fleas are opportunistic and will hop a ride into your home on your pant leg without you knowing it. Concentrate on areas under bushes, in the shade. Fleas are less likely to be located in open sunny areas where it gets hot.

You can also use borax. Sprinkle it into rugs, into corners and under furniture, use a broom to work it into the fibers and let it sit for hours, days even. It won’t hurt you or your pet to have it present. Then vacuum it up, reapply as needed. Food grade diatomaceous earth can be worked into the rugs and corners in the same way as borax. These treatments aren’t as fast and effective as chemical insecticides but they can help.

You might want to consider boarding your pet for the day at your vet, to give you the opportunity to flea bomb your house without having to worry about your pet being exposed. They can bathe your pet and give a dose of Capstar while you treat your home.

Be patient, you may have to repeat these steps multiple times 10-14 days apart to help break the life cycle.

Q. My dog has fleas and ticks. I’ve kept her area clean and bathed her. If I took her to the grooming salon, would they be able to help her issue?
ANSWER : A. To be honest with you, the groomer will do just about the same thing you have done for her at home, which is bathe your pet to rid all the fleas and flea eggs off of her that are currently on her.
However, the problem comes with re-infestation. Everytime your pet goes outside to potty and comes back inside, she has a potential to carry fleas in with her, even if she is only out there for a few minutes a day. In fact 40% of indoor pets has fleas, so we know that they can be extremely opportunistic.
The best and only way to protect your pet from fleas and ticks is by using a flea/tick preventative. Here are my top picks!:
1) Nexgard
2) Seresto collar
3) Advantix topical

These products are going to get the job done. Also you have to treat your home with a flea fogger (can be purchased at Home depot or Lowes) and wash all your pets bedding to help rid the flea eggs in the environment. This is key to overall flea ridding and flea control.

Q. My dogs were given Hartz ultrguard seven days ago. Can they be given frontline now because they still have fleas
ANSWER : A. In flea control, you get what you pay for. I would wait one more week before applying another product.

For every flea you see on your pet, there are 100 more in the environment. Get your pet on a good topical or oral flea control through your vet. In flea control, you get what you pay for. Consider asking your vet for a dose of Capstar. It helps get the problem under control by killing the fleas on the pet starting in five minutes but only lasts for 24 hours.

You need to treat your home environment. If you use a pest control service, tell them you are having a flea problem and they can adjust their treatment. Use a premise spray that also contains an IGR, insect growth regulator. This keeps eggs and larvae from maturing into adults and helps break the life cycle. Also, vacuum EVERY DAY, throwing out the bag or emptying the canister every time into an outside receptacle and spraying the contents with insecticide to kill the fleas you’ve vacuumed up.

Treat your yard too, since fleas are opportunistic and will hop a ride into your home on your pant leg without you knowing it. Concentrate on areas under bushes, in the shade. Fleas are less likely to be located in open sunny areas where it gets hot.

If chemicals are a problem, you can use borax. Sprinkle it into rugs, into corners and under furniture, use a broom to work it into the fibers and let it sit for hours, days even. It won’t hurt you or your pet to have it present. Then vacuum it up, reapply as needed. Food grade diatomaceous earth can be gotten from a health food store and worked into the rugs and corners in the same way as borax. These treatments aren’t as fast and effective as chemical insecticides but they can help.

Q. How can I remove internal ticks?
ANSWER : A. If you mean the ticks are embedded deeply in the skin, you can use a pair of tweezers to gently remove the tick. If the head becomes detached, most healthy bodies will push the head out of the skin naturally over a period of time. Using Vaseline over the tick can also sometimes cause it to back out on its own and be removed. Getting your dog on a monthly flea and tick preventative can help prevent future ticks from hopping on, also, if you are in an area where tick-borne disease are a problem it is always a good idea to have any tick bites examined by your local veterinarian.

If you mean the ticks were eaten, they will most likely pass through your dog without problem. However if you suspect there is an issue, your vet should take a look.