Experienced and professional animal trainer provide their insights in answering this question :
A. High level of this enzyme can be connected with many different disorders like muscle injury, trauma, endocrine diseases, neoplasm. Further investigation is needed to find out what is wrong

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CPK creatinine kinase elevations may be seen with inflammation, infection or. trauma within the muscle. In cats, anorexia may cause high CPK values. CREA creatinine reveals kidney function.
Healthy dogs showed activities in saliva of CK between 27 and 121 U/L and AST between 46 and 144 U/L, whereas in saliva of dogs with muscle damage CK ranged between 132 and 3862 U/L and AST between 154 and 4340 U/L.
In summary, renal injury with high serum CPK values becomes a true concern when levels of CPK reach 5,000 IU/L and the patient has serious co-morbid disease such as volume depletion, sepsis or acidosis. Otherwise, values of up to 20,000 IU/L may be tolerated without untoward event.
The CK ratio is elevated in patients with pancreatic adenocarcinoma and is an independent factor predicting pancreatic adenocarcinoma. The CK ratio augments the diagnostic capacity of CA19-9 in detecting malignancy.
CK is a specific enzyme marker of myofiber damage and a high serological CK activity in anorexic cats is usually associated with muscle catabolism, trauma, prolonged recumbency, hemolysis or hyperbilirubinemia.
Creatine kinase BB: a new tumor-associated marker.
Muscle diseases are the main source of plasma CK elevations: inherited myopathies, malignant hyperthermia, hypothyroidism, vitamin E-selenium deficiency, prolonged decubitus, intramuscular injections, surgery, etc.
CK levels can be mildly elevated (~500 U/L) in neuropathies like Charcot-Marie-Tooth disease or anterior horn cell diseases like spinal muscular atrophy, or grossly elevated (~3,000 to >30,000 U/L) in Duchenne muscular dystrophy or some other muscular dystrophies.
Normal CK levels can go as high as 400 U/L. In muscle injury, CK levels tend to rise in the first 12 hours and peak in 1 to 3 days, with levels remaining elevated for up to 5 days after resolution of the muscle injury. CK levels correlate with the degree of muscle injury and may correlate with the risk of AKI.
CK is a type of protein. The muscle cells in your body need CK to function. Levels of CK can rise after a heart attack, skeletal muscle injury, or strenuous exercise. They can also go up after drinking too much alcohol or from taking certain medicines or supplements.
It can be a life-threatening condition due to associated conditions such as acute renal failure, severe electrolyte abnormalities, and acid base disorders.
In our study, serum CK and LDH levels, important damage indicators, were higher in the dehydrated group than in the not dehydrated group. Among the dehydrated wrestlers, the high level of serum CK would have affected their performance negatively as well as restricted their movements because of muscle pains.
CK catalyzes the conversion of creatine and consumes ATP to create phosphocreatine (PCr) and ADP. This CK enzyme reaction is reversible and thus ATP can be generated from PCr and ADP [52].
Circulating CK is cleared by degradation in the liver and reticuloendothelial system and has a circulating half-life of 12 hours. Historically, CK has been used most often measured to diagnose acute myocardial infarction.
What is Metabolic Muscle Disease? The lack of ability to properly break down food causes two issues. First, your cat will not have the energy necessary to grow, regenerate, and use muscle tissue. Second, inappropriate amounts of by-products will build up in the muscle tissues of your cat, causing damage.
When the total CPK level is very high, it most often means there has been injury or stress to muscle tissue, the heart, or the brain. Muscle tissue injury is most likely. When a muscle is damaged, CPK leaks into the bloodstream. Finding which specific form of CPK is high helps determine which tissue has been damaged.
The CPK-MB test (creatine phosphokinase-MB), also known as CK-MB test, is a cardiac marker used to assist diagnoses of an acute myocardial infarction, myocardial ischemia, or myocarditis.
Serum CK (Creatine Kinase)

Serum CK begins to rise approximately 2 to 12 hours after the onset of muscle injury, peaks within 24 to 72 hours, and then declines gradually in 7–10 days.

Highlights. There is a linear correlation between creatine kinase and liver enzymes in war wounded with rhabdomyolysis. Severe rhabdomyolysis appears to be associated with liver damage. An increase in alkaline phosphatase and bilirubin in war wounded with rhabdomyolysis should suggest liver damage.
A serum CK level greater than 1,000 U/L in the presence of skeletal muscle injury is diagnostic for rhabdomyolysis. Serum CK is also a useful prognostic measure for the development of renal impairment, with levels of 5,000 U/L or greater being associated with increased risk of Acute Kidney Injury (AKI) [4].
This increase in CK, creatinine, and myoglobin levels can be associated with acute kidney injury because of kidney damage through tubular obstruction, oxidant injury, and vasoconstriction.
Characteristic laboratory findings – The laboratory findings that characterize rhabdomyolysis include an acute elevation in the CK and other muscle enzymes and a decline in these values within three to five days of cessation of muscle injury.
CK levels do vary depending on gender, race, age, muscle mass, and physical activity. In general, a healthy range in females is 30 to 145 U/L, and for males, it`s 55 to 170 U/L.
Creatine kinase (CK) was noticed to be related to the aggressive behavior in individuals with psychosis (Meltzer et al., 1980; Manor et al., 1998; Hermesh et al., 2002a, Hermesh et al., 2002b). Also known as creatine phosphokinase (CPK), CK consists of three isoenzymes: CK-MM, CK-MB and CK-BB.

Relevant Questions and Answers :

the most relevant questions and answers related to your specific issue

Q. My cats shows symptoms of hyperthyroidism but its thyroid test showed nothing wrong. The blood test only shows high liver enzyme. What shoukd i do?
ANSWER : A. If the blood test shows high liver enzymes I would recommend having a bile acid test done to check liver function. High liver enzymes, depending on how high, does not mean that the liver has loss of function, which is why a bile acid test is then done to gain more information here. For a cat this young, hyperthyroidism is very unlikely anyway.
I also recommend for any patient of mine with high liver enzymes to go on liver protectant medication (SAM-e or Denamarin) for 30 days to help protect the liver from an acute insult. Most of the time this is the extent of the medication needed if the bile acid comes back normal.

Q. Creatine kinase high?
ANSWER : A. High level of this enzyme can be connected with many different disorders like muscle injury, trauma, endocrine diseases, neoplasm. Further investigation is needed to find out what is wrong

Q. I have a yorkie/Chihuahua, 5 yrs. very very fussy eater – been told to feed her high protein, high fat, low carb food – is this right info – thanks
ANSWER : A. A well balanced, raw diet is desirable whenever possible. A dehydrated raw food like Only Natural Pet Easy Raw or Sojos usually works well with fussy eaters and you can adjust the amount of water you add to create more or less “gravy” depending on their preference. A high quality dehydrated raw is natural, balanced and essentially like a human food. http://www.onlynaturalpet.com/products/Only-Natural-Pet-EasyRaw-Dehydrated-Dog-Food/999244.aspx

Read Full Q/A … : How to Choose a Dog Food

Q. My girlfriends dog vomits every other day or 2. I dont know why? She already got 1 shot out of 3. Every2 weeks. Help?!
ANSWER : A. It’s possible that the dog has intestinal parasites, ate something it wasn’t supposed to, isn’t adapting to it’s current food, or something else. Just because it had one shot doesn’t mean it couldn’t be a disease like Parvo. Make sure your dog is on a high quality dog food, one that is high protein and doesn’t have a main ingredient of corn. A cheaper food doesn’t mean it’s going to be a better buy. The cheaper the food the more the dog needs to eat to gain energy from the food. When you buy a higher quality food your dog has to eat less to get the energy it needs and will poop less because it doesn’t have to eat as much. So with the high quality food you’re buying less and saving money that way. Please see a veterinarian with your vomiting concerns.

Q. My 8month old st Bernard has extremely high levels of calcium in his blood . Im waiting on more blood work to come back . Any suggettions
ANSWER : A. High Calcium level can be related to several conditions. It may be due to bone problems like bone infection or lysis. It is also not uncommon finding in patients suffering from tumors. Also overactive parathyroid gland can be responsible for high Calcium level. there are more possible causes but they are rather uncommon. Good luck with your dog and diagnosis.

Q. Is a high moisture content in a dog food important? If so, why are so many dry kibble foods so low in moisture? I want the best nutrition for my dog.
ANSWER : A. The moisture content itself is not vitally important and high moisture foods may be slightly more palatable but will deteriorate and go off much faster than those with lower moisture contents. It is important that a dog drinks sufficient water if on dry food. Ask your local vet clinic or petstore for locally available, high quality foods such as royal canin or hills

Q. We have two female cats who are sisters. One was just diagnosed with generalized lymphoma. Is there risk of being contageous? What kind of food
ANSWER : A. Lymphoma is a cancer and not a bacteria or virus, so it cannot be spread from cat to cat via contact. However, if your cats are related, they may both be genetically predisposed to getting the same type of cancer. Feline lymphoma can also sometimes be caused by the Feline Leukemia Virus (FeLV) or Feline Immunodeficiency Virus (FIV) which CAN be spread from cat to cat. The spread of these viruses is usually through bite wounds, saliva or fecal and urine matter, and the chances of spread among two amicable cats is lower, however testing both cats is always good.

As lymphoma can cause a decrease in appetite, sometimes the best food is one that will keep your cat on her normal eating routine so that she keeps her weight and energy up. Enticing her to eat by warming up wet foods, or even moistening and warming dry foods may encourage continued normal eating and may prevent weight loss from loss of appetite. A high-fat, high protein and low carbohydrate diet (such as a grain-free diet) may also help by providing a more calorie and nutrient dense meal so that every bite is beneficial.

Q. What brand of dog food should I feed my dog? She’s a husky mix and about 45 lbs. She’s almost 2 years old.
ANSWER : A. I would recommend Natural Balance at your local Petco store. Call the store and ask if they have a Natural Balance Brand rep who comes to the store and see when they come. Make sure the brand rep brings free samples with them. Normally they bring samples of the different flavors to the store and you should ask for some to try to see what your dog likes best. Offer the dog the different kibble and see which they prefer by holding them out in your hands and switch out the flavors. My dog prefered the Salmon based Natural Balance Synergy bag the best from all the flavors. I also found out he doesn’t care for the Bison Natural Balance even though a lot of dogs love it. The Petco may have free samples already so ask if they do. The pet store associates should be able to also assist you in finding the right food for you. The reason you want to go with a high quality high protein food vs the cheaper brands because they are grain free, no by products, and no corn. The cheaper brands have corn in it as the main ingredient and by product which is also very bad. When our dogs are forced to eat the cheaper brands they have to eat more to get the energy they need from the food resulting in more bowel movements and without the proper nutrients this can hurt their health later in life. The higher quality brands will be more cost per bag but you will be buying less because the dog eats less so you will be saving money that way and it comes out about even in the long run. Petco has a great Rewards Program so make sure to sign up and ask about the details on it. Every $100 you spend you get $5 in your email with the Pet Pals Reward Program.