Experienced and professional animal trainer provide their insights in answering this question :
A. This could certainly be a lot of things, but in very young puppies such as yours I worry about infectious problems, such as parasites or parvo virus, as well as foreign body ingestions (because puppies like to chew on things). I strongly recommend that you seek veterinary care as soon as possible, as continued fluid loss in very young animals is dangerous. He needs diagnostics in order to determine what’s going on, and then appropriate treatment.

How to Identify Common Pet Problems ?

Our sources include academic articles, blog posts, and personal essays from experienced pet care professionals :

Any kind of infection — including serious ones such as parvovirus, distemper, kennel cough, leptospirosis, and heartworm disease — can make your dog lethargic. Parvovirus is spread through feces. Symptoms of parvo can include lethargy, vomiting, diarrhea, and abdominal pain.
Dogs can have an upset stomach if they eat something too rich for them (which can lead to serious pancreatitis) or swallow an object that gets stuck. If a dog is so nauseous that they are acting listless and uncomfortable, they definitely need to be seen by a veterinarian.
Prompt attention from a veterinarian should be sought if your dog vomits multiple times in one day or for more than one day in a row. In addition, you should seek veterinary attention if your dog shows the following symptoms accompanied by vomiting: Loss of appetite. Change in frequency of urination.
Many gastrointestinal diseases can result in yellow vomit in dogs. Often, additional signs such as diarrhea, loss of appetite, or lethargy might also be observed if this is the case. Examples include irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), liver disease, or cancer in dogs.
If your dog is still vomiting even after not eating or drinking anything, it`s a sign that something more serious may be happening and you should seek medical attention for your dog immediately. This is especially true if your dog is lethargic, refuses food, or has a tender abdomen.
Recovery time usually is within a few days but sometimes can last a week or more. If left untreated, gastroenteritis can worsen and cause severe dehydration which can be life-threatening.
Vomiting or Diarrhea

It is not as concerning for your dog to vomit 2-3 times within 10 minutes and then be fine. If your dog vomits three or more times over a period of eight hours, you should be worried. If there is any blood in either, you should take your dog to the vet immediately.

Vomit may be clear or a yellow or brown color, and diarrhea will often contain blood and be a light yellow or mustard colored hue. In addition to vomiting frequently, your puppy may also appear to be drooling or foaming at the mouth as part of their parvo symptoms.
Dogs vomit all the time, but sometimes it can be serious. Digested blood appearing as black vomit, or bright red vomit is always an emergency and you should contact your vet immediately. On the other hand, a dog vomiting yellow or green liquid might not be harmful at all.
Protocol to Help Your Dog Rehydrate

Give water very gradually and slowly. Start off by giving one or two tablespoons every 15 minutes. If your dog vomits the water offered, you may try again in a couple of hours, but this time give ice cubes. If the dog still vomits, see your vet immediately.

You can recognize advancing dehydration in your dog by checking his or her skin`s elasticity. Gently pinch a small amount of skin on your dog`s back and release it. If your dog`s skin does not snap immediately back in place, your dog may be dehydrated. You can also check for dehydration by examining your dog`s gums.
A bland diet for dogs with gastroenteritis includes food like unseasoned, boiled chicken. Rehydration options include adding an electrolyte supplement to your dog`s water or giving your dog Gatorade or Pedialyte. Your veterinarian can recommend which rehydration option would be best for your dog.
Acute gastroenteritis usually goes away by itself; in other cases, it will progressively worsen until veterinary treatment is provided.
Symptoms caused by swallowed poisons can include: vomiting, diarrhoea, agitation and heart issues. Inhaled toxins may cause breathing difficulties or loss of consciousness in dogs. If your dog`s skin comes in contact with a poisonous substance typical symptoms include irritation and pain.
Typically, mild cases of poisoning have high recovery rates. In severe poisoning cases or cases where treatment was delayed the chance of recovery is extremely low. When pets do recover from severe poisoning there can also be long-term damage to their overall health.
Parvo smell has a unique very bad-smelling poop that is not easy to forget. The smell has been described as metallic, with hints of blood stench since the virus affects the intestinal walls, and a seemingly sweet scent.
Parasitic, Bacterial and Viral Infections – Infections causing lethargy and lack of appetite range from a simple case of a kennel cough; a respiratory disease treated with antibiotics, to more serious infections such as distemper, parvovirus or heartworm disease.
When signs of parvo start showing, the stool gets more watery, becoming brownish to black diarrhea with traces of blood. After signs of parvo start to show and diarrhea gets bloody and smelly, it`s a race against time because most dog fatalities happen within 2 to 3 days after the symptoms.
When a dog`s kidneys fail, toxins such as ammonia and nitrogen can build up in their bodies. This, in turn, can cause nausea, vomiting, and/or a decreased appetite. This condition is known as uremia, and it is directly related to kidney failure.
It is important to give your dog`s digestive system some time to recoup and rest from the vomiting by not feeding your dog for 12-24 hours. You can give your dog small amounts of water to keep them hydrated. Food and large amounts of water will only aggravate your dog`s upset stomach.
If the vomiting has not stopped within a day or two, medical attention should be sought to determine if the dog has a more serious disease, or if the vomiting has caused any metabolic disturbances.
The most common causes of lethargy in dogs are: Infection, including parvovirus, distemper, kennel cough and leptospirosis. Metabolic diseases, such as heart problems, liver problems, diabetes, and hypoglycaemia. Medications, such as newly prescribed drugs or a new flea or worm product.
It is important to note that many dogs may not show every clinical sign, but vomiting and diarrhea are the most common and consistent signs; vomiting usually begins first. Parvo may affect dogs of all ages but is most common in unvaccinated dogs less than one year of age.
The scent generally associated with parvo is caused by blood in the stool. Dogs with bloody stools because of hookworms have precisely the same smell. MORE IMPORTANTLY, if a puppy is diagnosed with Parvo BEFORE there is blood in the stool, the antivirals` effectiveness is MUCH GREATER.

Relevant Questions and Answers :

the most relevant questions and answers related to your specific issue

Q. Great Dane, Lab mix is vomiting, lethargic, bloodshot droopy eyes. No appetite. What’s wrong?
ANSWER : A. Vomiting is a common symptom of many illnesses which can range anywhere from minor digestive upset, to mores serious problems such as disease, illness or even bloat.

If your Dane Mix has only vomited once or twice, it may just indicate a minor stomach upset. Picking up food for a few hours then feeding a bland meal of boiled chicken and plain rice can help soothe the stomach and entice eating. However, if the vomiting continues or symptoms persist for more than a day, it may indicate something more serious going on and should be looked at by your vet.

Large and giant breed dogs are more prone to a condition called Bloat, which is considered a medical emergency. Signs of bloat in a dog include a large distended abdomen, pain in the abdomen, signs of distress such as heavy panting, pale gums or tongue, vomiting and diarrhea, or attempting to vomit or defecate without success. If you suspect your dog may be experiencing bloat, contacting your vet or emergency clinic immediately is best.

Q. My puppy is throwing up her food this morning and yellow foamy stuff. Please help!
ANSWER : A. If the vomiting has only occurred once, it may be due to the fact that there was something causing a minor upset stomach in your pup. Yellow foam is often acid, and tummies that are upset or that have been empty for too long can cause this to appear in vomit. It may just be that your puppy needs an extra meal in the day to help keep her stomach happy. Eating a meal too quickly can also cause a pup to vomit up undigested food and foam, and feeding smaller meals more often, or slowing down your dog’s eating can help.

If the vomiting has only happened once, pick up your puppy’s food for an hour or two and then offer a bland meal of plain boiled chicken and plain rice. These bland ingredients can help settle upset stomachs while being enticing “people food”. If the vomiting does not occur again, you can return to a normal feeding schedule.

However, if the vomiting continues, worsens, or new symptoms appear along with it, then it is a good idea to schedule an appointment with your vet to rule out any more serious causes.

Q. My dog has been throwing up a clear liquid (a little slimey) but otherwise acts fine. Could something be wrong?
ANSWER : A. How long has he been doing this? Ongoing vomiting (>2 weeks) warrants a vet visit, but if it’s a one-off, or happens very infrequently then it could be due to something he ate disagreeing with him. Is he is bright, alert and happy in himself I would monitor him, start keeping a vomit journal (seriously) of when he vomits, how much, what the vomit was like, what he was doing before and any other notes. This will be really useful for your vet if it requires further investigatoon. You can also try bland food – boiled chicken and white rice – in small amounts on his vomit days to give his tummy a rest. Withhold for 8h after a vomit and reintroduce the bland diet in small, frequent meals.

Q. My 3 month old puppy has had diarrhea, liquid form. This is the second day. What should I do? I recently changed his food as well.
ANSWER : A. Is he vomiting or lethargic? Food should always be introduced slowly over 7-10 days as that can cause diarrhea, if there are any other symptoms then contact you vet. Try introducing 3/4 of old food with 1/4 of new food for a few days & then half & half for a few days followed by 3/4 of new food with 1/4 old food for a few days before completely changing onto new diet.

Q. Changed dog’s food. Now throwing up and with diarrhea, what should I do?
ANSWER : A. Vomiting and diarrhea can occur if food is switched too quickly. Dogs generally need a slow changeover of foods over a period of a week or so to allow their guts and the gut bacteria to adjust. If there has only been one vomiting and diarrhea episode, removing the food for a few hours then feeding a bland diet of boiled chicken and plain rice can help soothe the stomach. You should then return to his old food and begin a gradual changeover of foods starting with 3 days of 75 old/25 new, 3 days of 50/50 and then 3 days of 25old/75 new. However if the vomiting and diarrhea symptoms do not improve, it may indicate something else causing his digestive distress and an appointment should be made with your local vet.

Q. My dog has been vomiting for 2 days. His food is fully digested and is coming up with a bunch of water. He vomits once or twice a day. Any suggestions
ANSWER : A. I would recommend starving for 12 hours and then gradually reintroduce a bland food. If the vomiting continues or he is very lethargic then you need to see your vet or emergency vet straight away.

Q. What are the typical symptoms for parvo, and what is the treatment?
ANSWER : A. Canine Parvovirus is an extremely contagious disease where infected animals shed billions of virus particles in their feaces during the illness and up to 2 weeks afterwards.

Infection occurs through the oro-feacal route, the virus is extremely resistant and can remain infectious for many months in the environment.

Clinical signs occur 5 days after being in contact with the virus and include anorexia, lethargy, vomiting and profuse diarrhea, often containing blood. Symptoms can progress to sepsis and other complications, leading to death especially in young puppies or in predisposed breeds such as Rottweilers and Dobermans.

Parvovirus is suspected in all young dogs presenting with vomiting and diarrhea, lethargy and leukopaenia. Severe leukopaenia corresponds to a poorer prognosis. Diagnosis can be confirmed on a faecal laboratory test, with positive results being considered a reliable indicator of positivity for the infection.

Treatment is supportive and aimed at restoring electrolytes imbalances, correcting dehydration, prevent secondary infections and controlling hypogliacaemia. Aggressive intravenous fluid therapy is required until vomiting stop and eating starts again. Initially small amount of bland diet should be fed and a gradual transition to the usual diet should be made. Vomiting can take up to 5 days to resolve.

Q. He is not eating or drinking seems like he has no energy and vomiting and seems like he weak
ANSWER : A. Causes of not eating and vomiting can be many. Gastrointestinal infection, caused by bacteria (salmonella, for example) or viruses or parasites (although parasite infections tend to be more mild, but giardia can make them feel pretty bad) can be a cause. Eating something he shouldn’t have, like the trash or rotten food can cause it. Intestinal obstruction can cause vomiting as well. Other causes (non-GI) of vomiting include kidney failure (can be due to many things, such as toxins, kidney stones, cancer) or liver diseases or liver failure.

The vomiting is concerning, however the weakness and lack of energy implies that he’s either seriously dehydrated or there’s a lot more going on than just s simple case of vomiting. He needs to see a vet and have testing, likely to include x-rays and/or blood work, to see what’s going on, so that it can be treated.