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A. I would recheck with a vet to see what the tear production is like and also add in Genteal ointment or drops to help with the dry eye. If it’s only dry eye you should be able to discontinue the neo poly bac, but the cyclosporine will also help so keep that up. Only way to know if it’s helping is to get a schirmer tear test done and see the values. Also I would recommend seeing an eye doctor for him to determine if there is more going on than just the dry eye, which is more than likely causing the ulcers.

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Side effects may include mild burning, stinging, irritation, or redness of the eyes, eyelid spasm, or loss of hair around the eye. More serious side effects include difficulty breathing or swelling of the throat, which could indicate an allergic reaction.
Neo-Poly-Bac is a medicated ointment prescribed to help treat bacterial eye infections in dogs. Applied directly, it treats conditions such as conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis to relieve irritated and infected eyes in pets.
Cyclosporine eye drops and ophthalmic ointment are used in dogs to treat dry eye and pannus. The veterinary term for dry eye is keratoconjunctivitis sicca or KCS. When used to treat KCS in dogs, cyclosporine causes increased tear production and decreases local inflammation in the eye and tear gland.
What Are the Risks? Individuals previously treated with methotrexate or other immunosuppressive agents, PUVA, UVB, coal tar, or radiation therapy are at an increased risk of developing skin cancer when taking cyclosporine. Additional risks with cyclosporine include kidney damage.
The clinical presentation may include tremors, restlessness, dysesthesias of the palms and soles, seizures, and altered mental status with confusion and visual or auditory hallucinations; cortical blindness, encephalopathy, and coma are less common.
This product contains neomycin, bacitracin, and polymyxin, which are antibiotics that work by stopping the growth of bacteria. It also contains hydrocortisone, which is an anti-inflammatory corticosteroid that works by reducing swelling.
I don`t think they`re quite the same – Viscotears (and all the other cheaper artificial tear products) can be very helpful for dry eyes (by providing lubrication) but am pretty sure Optimmune contains Cyclosporine (an immunosuppressant drug) which is why it is so expensive and is prescription only.
Are there any potential side effects from cyclosporine? The most common side effects of cyclosporine in dogs and cats are gastrointestinal side effects such as vomiting, diarrhea, and decreased appetite (anorexia). These side effects usually decrease over time.
How long should my dog take to respond to ciclosporin Optimmune? Most dogs show an improvement in the appearance of their eyes within two weeks of starting ciclosporin ointment. It can take up to six weeks for the increase in tear production to be maximal.
There are two commonly used ophthalmic medications to stimulate tear production, cyclosporine (brand name Optimmune®) and tacrolimus. Both are easily placed in the eyes once or twice daily. These drugs are very safe and most pets improve dramatically with their consistent use.
Symptoms of Dry Eye Syndrome in Dogs

Red, inflamed, irritated, and painful eyes. Redness and swelling of the conjunctiva, or the tissues around the eye. Frequent squinting and blinking. Dryness on the surface of the cornea—the outer clear dome-shaped part of the eye.

Avoid excessive intake of high potassium foods (bananas, oranges, orange juice, potatoes, spinach, etc). Do not eat grapefruits, grapefruit juice or any soda (Fresca) or fruit juice blend that contains grapefruit juice. Grapefruit can increase your levels of cyclosporine to a potentially toxic level.
Cyclosporine increases the risk of skin and lymphoid tissue malignancies in organ transplant patients. A similar increase has been shown among psoriasis patients, but no data exist on the carcinogenic risk of cyclosporine monotherapy in skin diseases.
Cyclosporine is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body`s ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.
This medicine may cause blurred vision or other vision problems. If any of these occur, do not drive or do anything else that could be dangerous until you know how this medicine affects you. While applying this medicine, your eyes will probably sting or burn for a short time. This is to be expected.
Your symptoms should begin to improve during the first few days of treatment with neomycin, polymyxin, and hydrocortisone otic combination. If your symptoms do not improve after one week or get worse, call your doctor.
Many people using this medication do not have serious side effects. Use of this medication for prolonged/repeated periods may result in a new fungal eye infection and may increase your risk for other eye problems (such as glaucoma, cataracts, delayed wound healing).
Neo-Polycin can treat infections in the eye and around the eyelid, such as pink eye, keratitis, and blepharitis, that are caused by common bacteria that affect the eye. Neo-Polycin can`t treat any eye infections that are caused by a virus or fungus.
What are the potential side effects of Neo Poly Dex Ophthalmic? Serious side effects are not expected when using this medication. However, some burning, stinging, irritation, itching, redness, blurred vision, eyelid itching, eyelid swelling, or sensitivity to light may occur.
Patients treated with the calcineurin inhibitors (CNIs) cyclosporine and tacrolimus are at high risk of developing kidney injury [1].
Dogs on cyclosporine may develop a thicker coat than usual and more shedding than usual can be expected. Other side effects reported include heavy callusing on the footpads, red/swollen ear flaps, and proliferation of the gums.
“Chronic dry eye may lead to ulcers that may become infected and rupture,” warns Dr. Martins. “Without the proper lubrication on the eye, pigment will build up over the cornea and result in permanent blindness.” If you have any questions about your pet`s eyes, please contact your local veterinarian.
Lots of factors affect drug prices. However, one common cause for higher consumer cost is a lack of competition. Restasis is a brand-name drug. These drugs are often under patent when first released, meaning no one else can manufacture them.
In most dogs however, dry eye is a permanent condition that cannot be cured, only controlled. Your pet will likely require some degree of medication long-term. Your ophthalmologist will work to slowly decrease medications over time to find the lowest maintenance level necessary to control the condition.

Relevant Questions and Answers :

the most relevant questions and answers related to your specific issue

Q. Joshua was put on Neo/Poly/Bac Optic Ointment & Optimune Cyclosporine 1% for dry eye and eye ulcers. It’s been 9 mo. since I can’t afford it?
ANSWER : A. I would recheck with a vet to see what the tear production is like and also add in Genteal ointment or drops to help with the dry eye. If it’s only dry eye you should be able to discontinue the neo poly bac, but the cyclosporine will also help so keep that up. Only way to know if it’s helping is to get a schirmer tear test done and see the values. Also I would recommend seeing an eye doctor for him to determine if there is more going on than just the dry eye, which is more than likely causing the ulcers.

Q. One eye is more red than the other. Last night he was pawing at it,today, he isn’t. Should I bring him to the vet?
ANSWER : A. Sounds possible that he had some irritation to the eye that is at least not itchy anymore. You can do either, having it checked now to confirm mild irritation, potentially due to debris or a topical irritant to the eye; or you can flush the eye with sterile saline eye wash (over the counter) using care not to poke or prod the eye and see if the irritation goes away on its own within the next 24 hrs. It has shown improvement already it appears, however if it is not cleared up and your pet seems irritated by it AT ALL, then it should be looked at by a vet and tested for a possible corneal scratch or ulcer. These can cause redness of the eye, eye discharge and pawing at the face. They are usually treated by prescription only topical eye antibiotic ointment and generally do very well after treatment.

Read Full Q/A … : Eye Problems in Cats

Q. Weak, discharge from eyes, swelling on right eye, does not want to open eyes. What is wrong?
ANSWER : A. If the discharge from the eye is green or yellow in color, it can indicate a secondary infection. Swollen eyes can be caused by a number of things ranging from allergies to infections, to injury to the eye itself or surrounding areas.

It is best to have your pet’s eye examined by your local vet. They will most likely wish to place a stain in the eye that can check for damage such as cuts or scratches. An ointment can then be given to help reduce inflammation, pain and take care of infection.

Until you can get to the vet, be sure to not let your pet scratch or paw at their eye as this can make things worse. You can also use a warm wet washcloth to gently remove any debris and allow the eye to open some, providing relief. However, if symptoms worsen, or the swelling travels to the face, head or neck, it may indicate a serious allergic reaction which should be treated immediately.

Q. My pet is suffering eyes discharge, what should I do?
ANSWER : A. Mucus, yellow-green pus, or a watery eye discharge can all be signs of conjunctivitis, which is inflammation of the lining of your dog’s eye.

There is a wide range of causes for conjunctivitis, from allergies, injury, birth defects, and tear duct problems, to foreign bodies, dry eye syndrome, infections or even tumors.

Other signs of conjunctivitis include excessive blinking or keeping the eye closed, squinting and pawing at the eyes.

Treatment of this condition depends on the underlying cause. In most of the cases cleaning, soothing the eye and applying antibiotics eye drops suffice but is some instances further investigation is required to establish the cause of the excessive eye discharge, and this should be performed by a veterinarian.

Q. I was told by my vet that my dogs cherry eye was caused by something hitting his eye when he was poking around under a bush. I was told surgery needed
ANSWER : A. Prolapsed gland of the eyelid refers to a pink mass protruding from the animal’s eyelid; it is also called a “cherry eye.” Normally, the gland is anchored by an attachment made up of fibrous material. The most common sign of “cherry eye” is an oval mass protruding from the dogs’s third eyelid. It can occur in one or both eyes, and may be accompanied by swelling and irritation. He may have acquired it by getting an injury to his eye but this isn’t the case sometimes. Sometimes there is a weakness in the fibrous attachment.

The veterinarian will review the mass in the dog’s third eyelid and determine if there is an underlying cause for the condition. The diagnosis of the prolapsed gland could be scrolled or everted cartilage in the third eyelid, abnormal cells in the third eye, or a prolapse of fat in the dog’s eye.

Treatment often includes surgical replacement of the gland in the dog’s eye, or removal of the entire gland if the condition is severe. Conversely, if medications are recommended, they are typically topical anti-inflammatory drugs that are effective in reducing swelling.

Q. My dog got into a fight with a cat. I think the cat scratch her eye. I clean it out with water. I have gentak can I put that in there?
ANSWER : A. It is best NOT to place anything in the eye unless specifically instructed to do so by your vet as it can cause more damage to the eye. As cat scratches and bites can easily become infected and the eye is a very sensitive area, it is best to schedule a veterinary appointment as soon as possible to have the eye examined. Your vet can place a fluorescent stain in the eye to check the extent of the damage and can then give you a pet-safe medication to place in it as needed to help it heal. Until you can get to the vet, it is best to keep the eye clean of debris and discharge with a warm wet washcloth, and to prevent your dog from scratching or clawing at the eye with the use of an Elizabethan (cone) collar.

Q. My 4 kittens eyes just opened up completely about 5 days ago. 3 of them have matted eyes in the morning. Will this eventually go away
ANSWER : A. It could be dry eyes or an infection. In the meantime go buy some genteal eye ointment at your local pharmacy and start placing that in the eyes every 12 hours to help lube the eyes. If that doesn’t work or if there is discharge that is green or yellow then it could be an infection and you will need meds for that, so you will need to find a veterinarian to treat that.

Q. What can be given to dogs to stop the brown draining around dogs eyes? I was told tetracycline would work.
ANSWER : A. Eye leakage is normal in some breeds of dogs, especially those that are more “bug-eyed” types. This eye leakage is just normal tears coming from the eye which can stain lighter colored coats. Unless there is an infection it does not need to be treated with antibiotics. Signs of infection usually include drainage that is thick or goopy and is yellow or greenish in color. Dogs with infections may also want to keep the eye closed, or may paw and scratch at it.

For plain tear-staining. Tear-stain wipes can be used around the eyes to remove the stain and bring the coat back to natural color. If infection is suspected, it is best to have your vet take a look at the eye prior to placing any medications in it.