Experienced and professional animal trainer provide their insights in answering this question :
A. Normally, besides the antibiotic, you would use one or the other, no rimadyl and prednisolone at the same time as increases the risk of gastric ulceration. In very exceptional cases you would use both, but needs to be monitored by a vet

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But it is important to remember that these medications should always be given separately. Combining prednisone (or other corticosteroids) with NSAIDs puts your pet at risk of developing serious health problems including gastrointestinal bleeding and perforation.
Prednisone can be an effective and safe treatment for a variety of conditions in dogs, including: For dogs with allergies, prednisone can help reduce inflammation and itching. For dogs with immune-mediated conditions, prednisone can help to suppress the immune system and reduce inflammation.
The following medications should be used with caution when given with prednisone/prednisolone: amphotericin B, anticholinesterases, aspirin, barbiturates, bupropion, cholestyramine, cyclophosphamide, cyclosporine, digoxin, potassium-depleting diuretics, ephedrine, estrogens, fluroquinolones, insulin, ketoconazole, …
Dogs taking long-term prednisone are more prone to fungal infections. They may also develop conditions like demodectic mange that we don`t expect to see in adult dogs. Taking a course of steroids may also throw off a dog`s thyroid function and cause liver enzyme elevations.
Your dog should be finished with the doxycycline, but still on the prednisone according to schedule. Exercise restriction is still important for the remainder of the prednisone schedule.
Trimeprazine tartrate with prednisolone (brand names: Temaril-P®, Vanectyl-P®) is a combination of an antihistamine and a corticosteroid used to treat itchiness (due to mostly allergies) or suppress cough. The combination is designed to decrease the amount of prednisone used.
The best way to treat skin allergies is to avoid the offending allergen. Flea allergies are usually the easiest to treat by killing the fleas and using a flea prevention medication. For food allergies, changing your dog`s diet can often do the trick.
Prednisone is a corticosteroid medication that`s FDA-approved for many inflammatory, autoimmune, and allergic health conditions. Prednisone should start to work within a couple hours, but it may be a couple days before you see its full effects.
Most dogs on prednisone will have increased thirst and urination along with a voracious appetite that can lead to weight gain. Restlessness and panting may also occur. These signs can gradually improve as the dog adjusts to the medication and should cease after the drug is stopped.
Long-term prescriptions last about three to four months. In critical conditions, the treatment period may increase. Various factors play an essential role in deciding how long your dog stays on prednisone. Some long-term uses of prednisone will be prescribed for life.
The most serious prednisone side effects usually include allergic reactions, infections, gastrointestinal issues and elevated blood sugar. These may occur when people take larger doses or take the medication for long-term treatment.
Steroid-related liver disease in dogs is the result of the dog being overly sensitive to steroid therapy. Steroids can cause lesions to occur on the liver as a result of negative changes in the liver cells, or hepatocytes.
All corticosteroids, including prednisone, carry the risk of interacting with quinolone antibiotics (levofloxacin, ciprofloxacin) and causing a tendon (tissue that connects muscle to bone) to rupture. Mixing prednisone and penicillin antibiotics such as amoxicillin is considered safe, says Madison.
For instance, muscle weakness and seizures are listed. So, if your dog is prescribed prednisone, watch them carefully for any signs of side effects, including weak and shaking hind legs.
One survey of owners has reported that dogs being treated with prednisolone become more vigilant and prone to startle, and it has been suggested that the long-term demand of hypervigilance can have negative psychological effects [16].
For many species, including dogs and humans, the two drugs are interchangeable, but cats and horses absorb prednisolone better than prednisone. The FDA (U.S. Food & Drug Administration) has approved some prednisolone products for use in dogs, cats, and horses.
Antihistamines with the active ingredients of diphenhydramine, chlorpheniramine, cetirizine, clemastine or loratadine are usually safe for most healthy adult dogs. Hydroxyzine is another dog-safe antihistamine and one of the most effective available, but it`s only available on prescription.
Steroids. Finally, in very serious cases of hot spots, your vet may prescribe steroids to your dog. Steroids are able to take down the inflammation in your dog`s body and reduce the irritation relating to hot spots. This in turn makes it easier for your dog to stop licking and chewing, which helps the hot spot clear up …
Organic, hypoallergenic and sulfate-free shampoos can calm your dog`s inflamed, itchy and irritated skin, especially with products that include natural anti-inflammatories such as aloe vera and tree tea oil.
Prednisone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.
Oral steroids, such as prednisone, also work by suppressing the immune system, thereby alleviating the swelling, itching, and redness. Your dermatologist may prescribe oral steroids in conjunction with antihistamines, such as loratadine or diphenhydramine, to effectively treat mild to moderate itching.
There`s a fair chance prednisone will make your dog depressed. It`s a recognized side effect. Dogs become withdrawn and antisocial.
Prednisone generally works very quickly — usually within one to four days — if the prescribed dose is adequate to reduce your particular level of inflammation. Some people notice the effects of prednisone hours after taking the first dose.
If you take oral corticosteroids for a long time, your adrenal glands may produce less of their natural steroid hormones. To give your adrenal glands time to recover this function, your provider may reduce your dose gradually.

Relevant Questions and Answers :

the most relevant questions and answers related to your specific issue

Q. My 11 yr. Old Golden has skin allergies. Is it ok to give him prednisone, an antibiotic and rimadyl (for arthritis) at the same time?
ANSWER : A. Normally, besides the antibiotic, you would use one or the other, no rimadyl and prednisolone at the same time as increases the risk of gastric ulceration. In very exceptional cases you would use both, but needs to be monitored by a vet

Q. My dog itchs all the time a codozon shot helps but don’t cure it after a bath she turns red and still itchs I changed dog food that didn’t help no fle
ANSWER : A. Do you live in a region where fleas are prevalent. Where I live the fleas are truly horrible, and I see many animals developing a flea allergy. This usually presents as relentless itching especially at the base of the tail, although it can be all over the body. Often on exam I won’t find a single flea, just red bumps, hair loss and itching. In response, I will start animals on an oral steroid such as prednisone (I think your doctor has administered an injectable steroid), while at the same time bathing the animal and starting on an oral flea preventative such as Comforts which I then re dose at 3 weeks instead of 4. Additionally, the environment needs to be decontaminated- flea bombing the house, vacuuming often and washing bedding on hot. The flea life cycle is short, however, so this needs to be one frequently as they will just continue to hatch in your home. Most importantly, I tell my clients, that any steroid (oral or injectable) does not fix the problem, but rather suppress your dogs reaction to it thereby making them more comfortable. Just the steroid alone changes nothing except giving them a brief break from their symptoms.

Now that I have spoken in depth about flea allergy, there is a potential that it is something else. Food allergies are slow to develop, and slow to change. If you wanted to eliminate a potential food allergy I would switch to a novel protein, limited ingredient diet. For example, lamb as the protein source if your previous food was always chicken or beef, and in a formula with very limited ingredients such as lamb, rice and veggies. A pet store should be able to help you with this. While on this diet they cannot have any additional treats for 1 month, to see if you have eliminated the allergy. From an Eastern Medical perspective, I also recommend novel proteins that are “cool”, such as fish, lamb, or duck while avoiding “warm” foods such as beef, chicken, pork.

Finally, all animals with allergies should be on an Omega 3 supplement. Given regularly, this can help reduce overall inflammation in the body both in the skin, joints, and other tissues. Good for allergies, arthritis and overall health. My dogs are on fish oils, but one of my dogs who is allergic to fish gets flax oil instead. I would be happy to consult with you further, but I hope this helps to some degree.

Q. My cat is excessively scrstching herself., to the point she has sores. She is strictly an indoor cat. Did have flees been treated for 2 months
ANSWER : A. For every flea you see on your pet, there are 100 more in the environment. Get your pet on a good topical or oral flea control through your vet. In flea control, you get what you pay for. Consider asking your vet for a dose of Capstar. It helps get the problem under control by killing the fleas on the pet starting in five minutes but only lasts for 24 hours.

You need to treat your home environment. If you use a pest control service, tell them you are having a flea problem and they can adjust their treatment. Use a premise spray that also contains an IGR, insect growth regulator. This keeps eggs and larvae from maturing into adults and helps break the life cycle. Also, vacuum EVERY DAY, throwing out the bag or emptying the canister every time into an outside receptacle and spraying the contents with insecticide to kill the fleas you’ve vacuumed up.

Treat your yard too, since fleas are opportunistic and will hop a ride into your home on your pant leg without you knowing it. Concentrate on areas under bushes, in the shade. Fleas are less likely to be located in open sunny areas where it gets hot.

If chemicals are a problem, you can use borax. Sprinkle it into rugs, into corners and under furniture, use a broom to work it into the fibers and let it sit for hours, days even. It won’t hurt you or your pet to have it present. Then vacuum it up, reapply as needed. Food grade diatomaceous earth can be gotten from a health food store and worked into the rugs and corners in the same way as borax. These treatments aren’t as fast and effective as chemical insecticides but they can help.

You might want to consider boarding your pet for the day at your vet, to give you the opportunity to flea bomb your house without having to worry about your pet being exposed. They can bathe your pet and give a dose of Capstar while you treat your home.

Be patient, you may have to repeat these steps multiple times 10-14 days apart to help break the flea life cycle.

Skin problems can have a variety of causes, sometimes more than one. It is important to have the problem checked by your vet to determine if there is a medical cause for your pet’s skin issues and treat accordingly.

In pets of all ages, fleas, food allergies and exposure to chemical irritants such as cleaners and soaps can be a cause. Any one of these may not be enough to trigger the breakouts, depending on how sensitive your pet is, but a combination can be enough to start the itch-scratch cycle. Finding out the cause and eliminating it is the best course of action. With flea allergies, if your pet is sensitive enough, a single bite can cause them to break out scratch enough to tear their skin.

Check for fleas with a flea comb. Look for fleas and/or tiny black granules, like coarse black pepper. This is flea feces, consisting of digested, dried blood. You may find tiny white particles, like salt, which are the flea eggs. Applying a good topical monthly flea treatment and aggressively treating your house and yard will help break the flea life cycle.

If you use plastic bowls, this is a possible cause for hair loss, though this tends to be on the chin, where their skin touches the bowl while they eat. If you suspect this to be the culprit, try changing the bowls to glass, metal or ceramic.

Food allergies are often caused by sensitivity to a protein in the food. Hill’s Science Diet offers some non-prescription options for sensitive skin as well as prescription hypoallergenic foods for more severe cases. Royal Canin carries limited protein diets that may also offer some relief. Your vet can recommend a specific diet that will help.

If there is no relief or not enough, consider getting your pet checked by a veterinary dermatologist and having allergy testing done.

Q. How can I keep my 14 year old Yorkie from snapping at the younger ones?
ANSWER : A. It’s all about management. Do not allow the 7yo’s to interact with your 14yo unsupervised. You should be there each time they interact so you can redirect the 14yo’s attention onto some toys, or onto some treats when the 7yo’s are around. It sounds like you need to help your 14yo make positive associations with being around the younger pups. You should be trying to feed him treats each time he interacts with them, and doesn’t snap at them. Pet and praise him each time he is around them, or any time they are near. As I said, keep the separated when you cannot supervise their interactions because if you aren’t around when he is snapping at them, you could end up with a fight on your hands.

It could also be that they spend too much time together. Imagine spending 100% of your time with somebody, day in and out, doing everything together… including going to the bathroom.. that might bother anybody. I think you should give them more time apart from each other. Take them all on separate walks, separate them to play with them individually, separate them when you take them to potty, separate feeding times in separate rooms, etc. This can help alleviate the stress your older dog is feeling due to living closely with other dogs. You should always be giving individual activities in a houseful of dogs anyway.. when you expect them to get along 100% of the time, that’s when you find trouble.

Q. We have a rescued female PitBull about 55lbs, who is always licking,biting or scratching herself raw. Most times it gets very bloody.How can I help?
ANSWER : A. These are common signs of allergies, but other causes such as fleas, mites or infection should be ruled out. Allergies can be frustrating to diagnose since they can develop at any time and have multiple causes (inhaled, food, contact). Schedule an appointment with your veterinarian for an exam and diagnostics (blood work, skin scrapes, cultures, etc). If the skin is broken or bloody, she is at risk for infection and requires antibiotics. Your vet can also prescribe a short course of steroids to break the itch cycle then can dispense or recommend an antihistamine to prevent the itchiness from returning. Some antihistamines work better than others in different dogs, so you will need to find the one that works best. A pet approved colloidal oatmeal bath can also soothe itchy, red skin. Consider adding an essential fatty acid supplement (usually a fish oil) to her diet to promote healthy skin. EFAs may also decrease inflammation. Search www.pet360.com for fish oil supplements. If she is diagnosed with allergies, your task is to try to determine what she is allergic to and decrease or eliminate it. Discuss food elimination trials and allergy testing with your vet.

Q. What can I get over the counter for Dermatitis in a 18 pound long haired Doxie?
ANSWER : A. Dermatitis can be caused by a number of things in dogs ranging from allergies, skin infections caused by bacteria or fungus, skin dryness from changes in the weather or too frequent bathing or even from external parasites. Determining the cause of the dermatitis first is best before treating it.

If allergies are thought to be the cause, allergy medication can be given to help relieve symptoms. Your vet can provide you with the correct dosage for your dog’s size of over the counter medications. In more serious cases, stronger allergy medications may need to be prescribed. For dry or flaky skin, using a shampoo that is for sensitive skin or oatmeal based can help soothe it. Lowering the frequency of baths and instead using a pet wipe or baby wipe to keep your dog clean will also help sooth the skin. For external parasites, starting on a preventive treatment plan of flea and tick medication will help stop fleas from biting and allow the skin to heal.

If you suspect a more serious causes such as bacterial or fungal infection, or your dog does not improve with treatment, making a wellness check with your vet is best. Your vet can thoroughly examine the skin and may also recommend additional tests to check for any underlying causes such as infection, hormonal imbalance or illness.

Q. My dogs skin has become red the vet said its an allergy to fleas yet he has none could it be an allergic reaction to my new carpet.
ANSWER : A. Skin problems can have a variety of causes, sometimes more than one. It is important to have the problem checked by your vet to determine if there is a medical cause for your pet’s skin issues and treat accordingly.

In pets of all ages, fleas, food allergies and exposure to chemical irritants such as cleaners and soaps can be a cause. Any one of these may not be enough to trigger the breakouts, depending on how sensitive your pet is, but a combination can be enough to start the itch-scratch cycle. Finding out the cause and eliminating it is the best course of action. With flea allergies, if your pet is sensitive enough, a single bite can cause them to break out scratch enough to tear their skin.

Check for fleas with a flea comb. Look for fleas and/or tiny black granules, like coarse black pepper. This is flea feces, consisting of digested, dried blood. You may find tiny white particles, like salt, which are the flea eggs. Applying a good topical monthly flea treatment and aggressively treating your house and yard will help break the flea life cycle.

If you use plastic bowls, this is a possible cause for hair loss, though this tends to be on the chin, where their skin touches the bowl while they eat. If you suspect this to be the culprit, try changing the bowls to glass, metal or ceramic.

Food allergies are often caused by sensitivity to a protein in the food. Hill’s Science Diet offers some non-prescription options for sensitive skin as well as prescription hypoallergenic foods for more severe cases. Royal Canin carries limited protein diets that may also offer some relief. Your vet can recommend a specific diet that will help.

If there is no relief or not enough, consider getting your pet checked by a veterinary dermatologist and having allergy testing done.

Q. My 12 year old cat is constantly grooming and scratching to the extent that she is pulling her hair out in spots. She is also losing weight.
ANSWER : A. Weight loss in older cats, especially when coupled with continued or increased appetite can indicate diabetes or hyperthyroidism. I recommend getting your cat in to see your vet as soon as possible for an exam and comprehensive labwork.

Skin problems can have a variety of causes, sometimes more than one. It is important to have the problem checked by your vet to determine if there is a medical cause for your pet’s skin issues and treat accordingly.

In pets of all ages, fleas, food allergies and exposure to chemical irritants such as cleaners and soaps can be a cause. Any one of these may not be enough to trigger the breakouts, depending on how sensitive your pet is, but a combination can be enough to start the itch-scratch cycle. Finding out the cause and eliminating it is the best course of action. With flea allergies, if your pet is sensitive enough, a single bite can cause them to break out scratch enough to tear their skin.

Check for fleas with a flea comb. Look for fleas and/or tiny black granules, like coarse black pepper. This is flea feces, consisting of digested, dried blood. You may find tiny white particles, like salt, which are the flea eggs. Applying a good topical monthly flea treatment and aggressively treating your house and yard will help break the flea life cycle.

If you use plastic bowls, this is a possible cause for hair loss, though this tends to be on the chin, where their skin touches the bowl while they eat. If you suspect this to be the culprit, try changing the bowls to glass, metal or ceramic.

Food allergies are often caused by sensitivity to a protein in the food. Hill’s Science Diet offers some non-prescription options for sensitive skin as well as prescription hypoallergenic foods for more severe cases. Royal Canin carries limited protein diets that may also offer some relief. Your vet can recommend a specific diet that will help.

If there is no relief or not enough, consider getting your pet checked by a veterinary dermatologist and having allergy testing done.